This American urban legend takes place in the desolate high desert of Arizona, where the Reynolds, an unsuspecting family, is systematically stalked by a malevolent shape shifting Skinwalker. Attacking their minds and bodies, the ancient spirit imprisons the family until Isiah, the charmingly awkward teenage son, is befriended by a local Native American shaman. While guiding Kenny into manhood, they join forces to destroy the murderous creatures and save his family.